1-[(3RS,4RS)-1-Benzyl-4-methylpiperidin-3-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine hemihydrate
نویسندگان
چکیده
The benzyl residue in the title compound, C(21)H(23)N(5)·0.5H(2)O, is oriented at a dihedral angle of 83.8 (3)° towards the 1,6-dihydro-imidazo[4,5-d]pyrrolo-[2,3-b]pyridine system. The piperidine ring adopts a chair conformation with the cis substituents displaying a torsion angle of -45.91 (16)°. In the crystal, mol-ecules are accumulated as racemic dimers by two inter-molecular hydrogen bonds between the pyrrolo-pyridine systems. Another hydrogen bond is formed between the imidazole ring and the cocrystallized water mol-ecule, which is located on a twofold rotation axis.
منابع مشابه
N-[(3RS,4SR)-1-Benzyl-4-methylpiperidin-3-yl]-1-(4-methylphenylsulfonyl)-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-amine
The structure of the title compound, C(27)H(29)N(5)O(4)S, displays an intra-molecular N-H⋯O hydrogen bond. The pyrrolo-[2,3-b]pyridine core makes a dihedral angle of 85.5 (4)° with the benzyl residue and a dihedral angle of 89.4 (9)° with the tosyl ring. The nitro group is slightly twisted out of the plane of the planar pyrrolo-pyridine system [(-N-)C-C-N-O torsion angle = -4.61 (18)° and (-NH-...
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عنوان ژورنال:
دوره 68 شماره
صفحات -
تاریخ انتشار 2012